Ganoderma lucidum extract is one of the active ingredients of Longevis. Ganoderma lucidum is a fungal organism whose pharmacological effects have been reported since 100 B.C. and concern the improvement of well-being, the increase of energy and vigour, and the extension of life span. The bioactive parts of Ganoderma lucidum with anti-aging functions include polysaccharides, triterpenes and peptides. They exert their anti-ageing effects essentially through contrasting oxidation, modulating the immune system and contrasting neurodegeneration. In addition to its effects on longevity, Ganoderma lucidum shows other healthy effects, such as anti-diabetes and anti-cancer effects. A clinical study has demonstrated the antioxidant, anti-aging and hepatoprotective nature of Ganoderma lucidum in humans. A mechanism of Ganoderma lucidum effects on longevity may involve its broad-spectrum immunomodulation effects, including the promotion of innate immune function, humoral immunity and cellular immunity. In particular, Ganoderma lucidum polysaccharides may support functions of cells of the immune system, including B and T lymphocytes, dendritic cells, macrophages and natural killer cells.